CNS鉴读肿瘤免疫治疗引起结肠炎症的

肿瘤免疫治疗引起结肠炎症的分子途径

Highlights

?Mechanismsofinflammatoryadverseeventsinducedbycheckpointblockade

?Colitis-associateddifferentiationofCD8Trmcellstocytotoxiceffectorcells

?PersistenceandexpansionofCTLA-4+Tregcells

?Inflammatorypathwaysprovideopportunitiesfortherapeuticintervention

Summary

CheckpointblockadewithantibodiesspecificforthePD-1andCTLA-4inhibitoryreceptorscaninducedurableresponsesinawiderangeofhumancancers.However,theimmunologicalmechanismsresponsibleforsevereinflammatorysideeffectsremainpoorlyunderstood.Herewereporta

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